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"Dopant Catalyzed Charge Dissipation
in a Liquid Crystal"
(Krishnan and Garnett, 203rd Meeting of Electrochemical Society, Abstract 2703,
Paris 2003)
C.V.Krishman, Merrill Garnett And John L. Remo
Garnett McKeen Lab Inc.
150 Islip Ave. Suite 6
Islip, New York 11751, USA
Palladium and lipoid acid have been combinated in 1:1 stoichiometry to form a
liquid crystal polymer complex (PLA). PLA is an investigative chemotherapy compound which transfers charge to DNA
(1,2). PLA dries to form a fern pattern (fig.1), and undergoes a geometric transform from magnetic fields introduced
during drying (Freedericks transition )(fig.2). PLA was synthesized in its 1:1 core form for this study, without
edition of co-reactants used in its clinical formulation. The PLA is studied by modification of electronic impedance
spectroscopy in which controlled charge dissipation is allowed at the threshold of electrode polarization. This
attempts to simulate the ion streaming in cell membranes which accompanies biologic oscillatory depolarization
and repolarization, best studied in cardiac and nerve tissue.
Alkaline PLA (pH range from 7.3 to 12.3) at .04m, calculated monomer, is diluted with de-ionizedter. The PLA contains
NaCI from the method of synthesis, and no additional background electrolyte is necessary. The diluted PLA is analyzed
in an Ecochemie Autolab electro-chemistry system using a PAR mercury electrode stand. Impedance spectroscopy is
performed at mercury oxidation threshold voltages to locate this boundary condition. A log series of 49 frequencies
from1KHz to 50MHz is scanned with 5 mv perturbations. Within 10 mv. bands, in a range from+.01 to +.38 V as a function
of pH, EIS produces a conventional capacitive segment followed by a large counter-clockwise (reverse) curvature
extending into the upper left quadrant of the complex plane(+.01 V: fig 3). The counter-clockwise curve has a smooth
circle fit. An equivalent circui- RI(Q1<R2_WI>) is expressed. A convergence to negative DC resistance, appears
to be a discharge of a capacitive layer. The narrow voltage band is thought to limit the electrode corrosion to
a small amount of Hg+1, which acts as a dopant hole in the PLA liquid crystal.
The magnitude of the charge dissipation (current reversal), is correlated with the movement of both electrons and
cation hole, a condition which has been called ambipolar and modeled in depth(3).
This catalytic charge transfer in a liquid crystal is a new paradigm in
cancer chemotherapy.
References:
1. Garnett,M., U.S.Patent No 5463,093-Oct.31,1995
2. Garnett, M., Remo J.L.,
Microfabricated Systems and Mems V, Proc., 2000-19:185-190,ECS,2000.
3. Emiliani,V ., Frova A., Presilla,C,
Superlattices and Microstructures,20: No.1,1-5,1996
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